DigiBuzz-VTT – Towards digital twin’s concrete commercial exploitation

The DigiBuzz-VTT project, a part of the DigiBuzz common effort, focused on the applications of digital twins in manufacturing industry ecosystems. The DigiBuzz-VTT project had two main focuses, 1) functional digital twins, or simulation-based digital twins, of machines and machine systems and their applications, and 2) the life cycle management of digital twins (the digital part of the twin), emphasising data modelling and data management. These themes were studied from the technical and from the business point of views. The detailed research topics were:• Business opportunities and added value of digital twins for manufacturing industry• Data-based digital twins, use of machine learning for feature recognition• The status of standardisation for the lifecycle data management of digital twins, means for preserving model data• Hybrid modelling with digital twins, combination of experimental and simulation data• The optimisation of the measurement points location, method development• The use of Kalman filters in estimating simulation data correlation with measured data• The status of Industrial Internet of Things (IIoT) for digital twinsThis report summarises the implementation of the DigiBuzz-VTT project and lists the main deliverables of the project. The project produced several scientific articles and research reports, which report the research results in detail

Data in sustainable production chain management

The aim of this paper is to innovate the role of data in sustainable production chain management by identifying drivers, challenges and future solutions related to sustainability and data utilisation. The research data was collected from a literature review, a sustainability seminar entitled “Strong Stronger Responsible” and interviews with company representatives. The interviewees represented operators in the renewable forest and chemical industries and the companies serving them. This study examines sustainability data on the wood fibre-based production chain, from the forest to the consumer. The results show that for sustainability data, production chains have challenges and development needs in terms of indicators, data collection, quality and sharing. Sustainability data should guide decision making in processes at all levels of the organisation, as well as in the production chain

Data in sustainable production chain management

The aim of this paper is to innovate the role of data in sustainable production chain management by identifying drivers, challenges and future solutions related to sustainability and data utilisation. The research data was collected from a literature review, a sustainability seminar entitled “Strong Stronger Responsible” and interviews with company representatives. The interviewees represented operators in the renewable forest and chemical industries and the companies serving them. This study examines sustainability data on the wood fibre-based production chain, from the forest to the consumer. The results show that for sustainability data, production chains have challenges and development needs in terms of indicators, data collection, quality and sharing. Sustainability data should guide decision making in processes at all levels of the organisation, as well as in the production chain

Wintertime subarctic new particle formation from Kola Peninsula sulfur emissions

The metallurgical industry in the Kola Peninsula, north-west Russia, form, after Norilsk, Siberia, the second largest source of air pollution in the Arctic and subarctic domain. Sulfur dioxide (SO2/emissions from the ore smelters are transported to wide areas, including Finnish Lapland. We performed investigations on concentrations of SO2, aerosol precursor vapours, aerosol and ion cluster size distributions together with chemical composition measurements of freshly formed clusters at the SMEAR I station in Finnish Lapland relatively close (similar to 300 km) to the Kola Peninsula industrial sites during the winter 2019-2020. We show that highly concentrated SO2 from smelter emissions is converted to sulfuric acid (H2SO4/in sufficient concentrations to drive new particle formation hundreds of kilometres downwind from the emission sources, even at very low solar radiation intensities. Observed new particle formation is primarily initiated by H2SO4-ammonia (negative-)ion-induced nucleation. Particle growth to cloud condensation nuclei (CCN) sizes was concluded to result from sulfuric acid condensation. However, air mass advection had a large role in modifying aerosol size distributions, and other growth mechanisms and condensation of other compounds cannot be fully excluded. Our results demonstrate the dominance of SO2 emissions in controlling wintertime aerosol and CCN concentrations in the subarctic region with a heavily polluting industry.Peer reviewe

Solar eclipse demonstrating the importance of photochemistry in new particle formation

Solar eclipses provide unique possibilities to investigate atmospheric processes, such as new particle formation (NPF), important to the global aerosol load and radiative balance. The temporary absence of solar radiation gives particular insight into different oxidation and clustering processes leading to NPF. This is crucial because our mechanistic understanding on how NPF is related to photochemistry is still rather limited. During a partial solar eclipse over Finland in 2015, we found that this phenomenon had prominent effects on atmospheric on-going NPF. During the eclipse, the sources of aerosol precursor gases, such as sulphuric acid and nitrogen-containing highly oxidised organic compounds, decreased considerably, which was followed by a reduced formation of small clusters and nanoparticles and thus termination of NPF. After the eclipse, aerosol precursor molecule concentrations recovered and reinitiated NPF. Our results provide direct evidence on the key role of the photochemical production of sulphuric acid and highly oxidized organic compounds in maintaining atmospheric NPF. Our results also explain the rare occurrence of this phenomenon under dark conditions, as well as its seemingly weak connection with atmospheric ions.Peer reviewe

Loss of DIAPH1 causes SCBMS, combined immunodeficiency, and mitochondrial dysfunction

Background: Homozygous loss of DIAPH1 results in seizures, cortical blindness, and microcephaly syndrome (SCBMS). We studied 5 Finnish and 2 Omani patients with loss of DIAPH1 presenting with SCBMS, mitochondrial dysfunction, and immunodeficiency. Objective: We sought to further characterize phenotypes and disease mechanisms associated with loss of DIAPH1. Methods: Exome sequencing, genotyping and haplotype analysis, B- and T-cell phenotyping, in vitro lymphocyte stimulation assays, analyses of mitochondrial function, immunofluorescence staining for cytoskeletal proteins and mitochondria, and CRISPR-Cas9 DIAPH1 knockout in heathy donor PBMCs were used. Results: Genetic analyses found all Finnish patients homozygous for a rare DIAPH1 splice-variant (NM_005219:c.68411G>A) enriched in the Finnish population, and Omani patients homozygous for a previously described pathogenic DIAPH1 frameshift-variant (NM_005219:c.2769delT;p.F923fs). In addition to microcephaly, epilepsy, and cortical blindness characteristic to SCBMS, the patients presented with infection susceptibility due to defective lymphocyte maturation and 3 patients developed B-cell lymphoma. Patients' immunophenotype was characterized by poor lymphocyte activation and proliferation, defective B-cell maturation, and lack of naive T cells. CRISPR-Cas9 knockout of DIAPH1 in PBMCs from healthy donors replicated the T-cell activation defect. Patient-derived peripheral blood T cells exhibited impaired adhesion and inefficient microtubule-organizing center repositioning to the immunologic synapse. The clinical symptoms and laboratory tests also suggested mitochondrial dysfunction. Experiments with immortalized, patient-derived fibroblasts indicated that DIAPH1 affects the amount of complex IV of the mitochondrial respiratory chain. Conclusions: Our data demonstrate that individuals with SCBMS can have combined immune deficiency and implicate defective cytoskeletal organization and mitochondrial dysfunction in SCBMS pathogenesis.Peer reviewe